Effect of Folic Acid in Sepsis-induced Lung Damage in Rats-Reference-Cited by-同舟云学术

Effect of Folic Acid in Sepsis-induced Lung Damage in Rats

Published:2023-10-19 Issue:Supplement (1) Volume:5 Page:87-92
ISSN:2687-4555
Container-title:Medical Records
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Author:

YURTSEVER Guner¹^ORCID,BORA Ejder Saylav²^ORCID,EROĞLU Ebru³^ORCID,UYANIKGİL Yiğit⁴^ORCID,ERDOĞAN Mümin Alper⁵^ORCID,ERBAŞ Oytun⁶^ORCID

Affiliation:

1. İzmir Atatürk eğitim araştırma hastanesi

2. Izmir Atatürk Training and Research Hospital

3. EGE UNIVERSITY, EGE FACULTY OF MEDICINE

4. EGE ÜNİVERSİTESİ, EGE TIP FAKÜLTESİ

5. IZMIR KATIP CELEBI UNIVERSITY

6. İSTANBUL BİLİM ÜNİVERSİTESİ, TIP FAKÜLTESİ

Abstract

Aim: Sepsis-induced lung injury remains a critical concern with significant morbidity and mortality. This study aimed to investigate the potential therapeutic role of Folic Acid in mitigating lung injury induced by sepsis while exploring its interaction with the soluble suppression of tumorigenicity 2 (sST2) protein in an experimental rat model. Material and Methods: Rats were divided into three groups: a normal control group, a group induced with sepsis and treated with saline, and a group induced with sepsis and treated with Folic Acid (5 mg/kg). Biomarkers of oxidative stress, inflammation, respiratory gas exchange, and lung histopathology were assessed. Results: Folic Acid administration resulted in significantly decreased Malondialdehyde (MDA) levels (p

Publisher

Medical Records - International Medical Journal

Subject

Colloid and Surface Chemistry,Physical and Theoretical Chemistry

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