Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis-Reference-Cited by-同舟云学术

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

Published:2019-05-28 Issue:20 Volume:321 Page:2003
ISSN:0098-7484
Container-title:JAMA
language:en
Short-container-title:JAMA

Author:

Seymour Christopher W.¹²³,Kennedy Jason N.¹³,Wang Shu⁴,Chang Chung-Chou H.³⁴⁵,Elliott Corrine F.⁶,Xu Zhongying⁴,Berry Scott⁶,Clermont Gilles¹³,Cooper Gregory⁷,Gomez Hernando¹²³,Huang David T.¹²³,Kellum John A.¹³,Mi Qi⁸,Opal Steven M.⁹,Talisa Victor⁴,van der Poll Tom¹⁰,Visweswaran Shyam⁷,Vodovotz Yoram¹¹,Weiss Jeremy C.¹²,Yealy Donald M.²,Yende Sachin¹³¹³,Angus Derek C.¹³⁵

Affiliation:

1. Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

2. Department of Emergency Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

3. Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

4. Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania

5. Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

6. Berry Consultants, Austin, Texas

7. Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania

8. Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania

9. Department of Medicine, Infectious Disease Division, Rhode Island Hospital, Providence

10. Center of Experimental and Molecular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands

11. Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania

12. Machine Learning Department, Carnegie Mellon University, Pittsburgh, Pennsylvania

13. Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

http:///jama/article-pdf/321/20/2003/17611365/jama_seymour_2019_oi_190047.pdf

Reference28 articles.

1. Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009-2014.;Rhee;JAMA,2017

2. Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3).;Seymour;JAMA,2016

3. Classification of patients with sepsis according to blood genomic endotype.;Scicluna;Lancet Respir Med,2017

4. Unsupervised analysis of transcriptomics in bacterial sepsis across multiple datasets reveals three robust clusters.;Sweeney;Crit Care Med,2018

5. Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study.;Davenport;Lancet Respir Med,2016

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