A Facile One‐Pot Synthesis of N 4‐Alkyloxycarbonyl Cytosine Nucleosides

Author:

Chen Yue‐Lei1,Cen Jun‐Da1

Affiliation:

1. a Department of Chemistry , Shanghai Institute of Pharmaceutical Industry , Shanghai, 200437, P.R. China

Publisher

Informa UK Limited

Subject

Organic Chemistry

Reference13 articles.

1. Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine

2. Synthesis and biological activity of the new 5-fluorocytosine derivatives, 5′-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5′-carboxylic acid

3. The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine

4. Arasaki , M. N.R. Ishitsuka , H. Kuruma , I. Miwa , M. Murasaki , C. Shimma , N. and Umeda , I. I.H. N‐Oxycarbonyl‐substituted 5′‐deoxy‐5‐fluorocytidines as antitumor agents. EP 602,454. June 22, 1994.

5. Hertel , L. W. and Kroin , J. S. 2′‐Deoxy‐2′,2′‐difluoro‐(4‐substituted pyrimidine) nucleosides having antiviral and anti‐cancer activity and intermediates. EP 576,230. December 29, 1993.

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