Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine-Reference-Cited by-同舟云学术

Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine

Published:2003-03 Issue:5 Volume:13 Page:867-872
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Hattori Kazuo,Kohchi Yasunori,Oikawa Nobuhiro,Suda Hitomi,Ura Masako,Ishikawa Tohru,Miwa Masanori,Endoh Mika,Eda Hiroyuki,Tanimura Hiromi,Kawashima Akira,Horii Ikuo,Ishitsuka Hideo,Shimma Nobuo

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Tumor Selective Delivery of 5-Fluorouracil by Capecitabine, a New Oral Fluoropyrimidine Carbamate, in Human Cancer Xenografts

2. The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine

3. Structure-activity relationship of ligands of dihydrouracil dehydrogenase from mouse liver

Cited by 25 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Dihydropyrimidine Dehydrogenase-Mediated Resistance to 5-Fluorouracil: Mechanistic Investigation and Solution;ACS Pharmacology & Translational Science;2022-10-06

2. Molecular modeling approaches to address drug-metabolizing enzymes (DMEs) mediated chemoresistance: a review;Drug Metabolism Reviews;2021-01-02

3. Biomimetic Gemcitabine–Lipid Prodrug Nanoparticles for Pancreatic Cancer;ChemPlusChem;2020-06

4. Drug metabolizing enzymes-associated chemo resistance and strategies to overcome it;Drug Metabolism Reviews;2019-04-03

5. Drug delivery of oral anti-cancer fluoropyrimidine agents;Expert Opinion on Drug Delivery;2017-04-11