Mechanism of positive electret inhibition of Staphylococcus aureus biofilms
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Published:2023-10-31
Issue:4
Volume:6
Page:282-289
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ISSN:2514-3255
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Container-title:IET Nanodielectrics
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language:en
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Short-container-title:IET Nanodielectrics
Author:
Wang Hongbao1,
Liang Hejuan2,
Guo Xin2,
Xu Jiajie2,
Jiang Jian2,
Sun Zhipeng2,
Liang Yuanyuan2ORCID
Affiliation:
1. School of Health Science and Engineering University of Shanghai for Science and Technology Shanghai China
2. Department of Physics and Mathematics College of Basic Medical Sciences Naval Medical University Shanghai China
Abstract
AbstractBacterial biofilm is an important factor in bacterial drug resistance. Recently, it has been proved that electret films can inhibit the bacterial biofilm, while its mechanism of action on biofilms is under further investigation. In this work, taking Staphylococcus aureus as an example, the inhibition of positive electret on bacterial biofilm was verified and its mechanism was explained. Two factors have been found to explain the inhibition mechanism of electret on bacterial biofilms. One is probably due to its inhibition of the expression of key genes related to bacterial biofilms induced by the electric field of positive electret, and the other is to prevent the aggregation of bacteria rather than the direct bactericidal effect. The conclusions are expected to be extended to other types of bacteria and expand the application of electrostatic materials in the field of biomedicine.
Funder
Natural Science Foundation of Shanghai Municipality
Publisher
Institution of Engineering and Technology (IET)
Subject
Materials Chemistry,Electrical and Electronic Engineering,Condensed Matter Physics,Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials