Nosocomial infections causedby Pseudomonas aeruginosa in cancer clinics-Reference-Cited by-同舟云学术

Nosocomial infections causedby Pseudomonas aeruginosa in cancer clinics

Published:2019-04-26 Issue:2 Volume:18 Page:28-34
ISSN:2312-3168
Container-title:Siberian journal of oncology
language:
Short-container-title:Sib. onkol. ž.

Author:

Dmitrieva N. V.¹,Eidelshtein M. V.²,Aginova V. V.³,Perukhova I. N.¹,Grigorievskaya Z. V.¹,Bagirova N. S.¹,Tereshchenko I. V.¹,Kulaga E. V.¹,Klyuchnikova I. A.¹,Sokolova E. N.¹,Shek E. A.²,Skleenova E. Yu.²

Affiliation:

1. N.N. Blokhin National Medical Research Center of Oncology.

2. Research Institute of Antimicrobial Chemotherapy, Smolensk State Medical University.

3. N.N. Blokhin National Medical Research Center of Oncology; Medical college №1.

Abstract

The purpose of the study was to evaluate the frequency of isolation of multi-resistant Pseudomonas aeruginosa and identify the mechanisms of resistance to carbapenems.Material and methods. We analyzed 866 strains of Pseudomonos aeruginosaisolated from clinical samples from cancer patients in the period 2014–2016. the level of resistance to piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, ciprofloxacin, amikacin in dynamics was determined. carbapenem-resistant (car-R) strains were examined for the presence of enzymes.Results. Between 2014 and 2016, the number of strains resistant to piperacillin/tazobactam was 20.1–12.9 %, to ceftazidime – 33.0–32.9 %, to cefepime – 25.6–32.9 %, ciprofloxacin – 36.8–43.8 %, amikacin – 23.8–24.9 %. No statistically significant differences were found (p>0.05). However, an increase in the number of car-R strains from 31.7 to 43.8 % was observed (p<0.05). of 7 strains of P. aeruginosainvestigated for the presence of acquired carbapenemases, the production of metal-beta-lactamase of group Vimwas detected in 2 strains, and class acarbapenemases of the gEs-5 group in one strain.Conclusion. P. aeruginosaresistance to all antibiotic groups did not exceed 50 % and remained almost unchanged for 3 years, with the exception of the increase in car-R strains. three out of 7 (42.9 %) carbapenem-resistant strains were genetically stable.

Publisher

Tomsk Cancer Research Institute

Subject

Cancer Research,Oncology

Reference14 articles.

1. Григорьевская З.В., Петухова И.Н., Дьякова С.А., Дмитриева Н.В. Эпидемиология внутрибольничных инфекций в онкологическом стационаре. Сибирский онкологический журнал. 2016; 15 (3): 62–66. [Grigorievskaya Z.V., Petukhova I.N., Dyakova S.A., Dmitrieva N.V. Epidemiology of hospital-acquired infections caused by highly resistant strains in cancer patients. Siberian Journal of Oncology. 2016; 15 (3): 62–66. (in Russian)]. doi: 10.21294/1814-4861-2016-15-3-62-66.

2. Дмитриева Н.В., Петухова И.Н., Багирова Н.С. Резистентность микроорганизмов – возбудителей инфекций у онкологических больных. Сопроводительная терапия в онкологии. 2005; 1: 17. [Dmitriyeva N.V., Petukhova I.N., Bagirova N.S.The resistance of microorganisms – pathogens in cancer patients. Current Therapy in Oncology. 2005; 1:17. (in Russian)].

3. Демиховская Е.В. Неферментирующие бактерии в аспекте множественной антибиотикорезистентности возбудителей внутрибольничных инфекций. Болезнь и антибиотики. 2012; 1 (6): 88–95. [Demikhovskaya Ye.V. Non-fermenting bacteria in the aspect of multiple antibiotic resistance of pathogens of nosocomial infections. Disease and Antibiotics 2012; 1(6): 88–95. (in Russian)].

4. Решедько Г.К., Рябкова Е.Л., Фаращук А.Н., Страчунский Л.С., Туркутюков В.Б., Нехаева Г.И., Розанова С.М., Боронина Л.Г., Агапова Е.Д., Марусина Н.Е., Мултых И.Г., Тарабан В.К., Здзитовецкий Д.Э., Сарматова Н.И., Тихонов Ю.Г., Поликарпова С.В., Большаков Л.В., Богомолова Н.С., Дмитриева Н.В., Петухова И.Н., Галеева Е.В., Круглов А.Н., Вышелесская Н.Д., Александрова И.А., Белобородова Н.В., Вострикова Т.Ю., Ильина В.Н., Иванова С.Ф., Скальский С.В., Зубарева Н.А., Суборова Т.Н., Кречикова О.И., Щетинин Е.В., Николаева Т.А., Мартьянова Н.М., Гудкова Л.В., Ортенберг Э.А., Ушакова М.А., Хасанова С.Г., Габбасова Л.А., Колесник Т.И., Торопова И.А., Палютин Ш.Х., Монахова С.И.Неферментирующие грамотрицательные возбудители нозокомиальных инфекций в ОРИТ России: проблемы антибиотикорезистентности. Клиническая микробиология и антимикробная химиотерапия. 2006; 8 (3): 243–259. [Reshed'ko G.K., Ryabkova Ye.L., Farashchuk A.N., Strachunskiy L.S., Turkutyukov V.B., Nekhayeva G.I., Rozanova S.M., Boronina L.G., Agapova Ye.D., Marusina N.Ye., Multykh I.G., Taraban V.K., Zdzitovetskiy D.E., Sarmatova N.I., Tikhonov Yu.G., Polikarpova S.V., Bol’shakov L.V., Bogomolova N.S., Dmitriyeva N.V., Petukhova I.N., Galeyeva Ye.V., Kruglov A.N., Vyshelesskaya N.D., Aleksandrova I.A., Beloborodova N.V., Vostrikova T.Yu., Il’ina V.N., Ivanova S.F., Skal’skiy S.V., Zubareva N.A., Suborova T.N., Krechikova O.I., Shchetinin Ye.V., Nikolayeva T.A., Mart’yanova N.M., Gudkova L.V., Ortenberg E.A., Ushakova M.A., Khasanova S.G., Gabbasova L.A., Kolesnik T.I., Toropova I.A., Palyutin Sh.Kh., Monakhova S.I.Non-fermentative Gram-negative Pathogens of Nosocomial Infections in the Departments of Intensive Therapy in Russia: Problems of Antibiotic Resistance. Clinical Microbiology and Antimicrobial Chemotherapy. 2006; 8 (3): 243–259. (in Russian)].

5. Parkins M.D., Gregson D.B., Pitout J.D., Ross T., Laupland K.B. Population-based study of the epidemiology and the risk factors for Pseudomonas aeruginosa bloodstream infections. Infection. 2010 Feb; 38 (1): 25–32. doi: 10.1007/s15010-009-9145-9.

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