CRISPR-Cas9 In Vivo Gene Editing of KLKB1 for Hereditary Angioedema

Author:

Longhurst Hilary J.1,Lindsay Karen1,Petersen Remy S.1,Fijen Lauré M.1,Gurugama Padmalal1,Maag David1,Butler James S.1,Shah Mrinal Y.1,Golden Adele1,Xu Yuanxin1,Boiselle Carri1,Vogel Joseph D.1,Abdelhady Ahmed M.1,Maitland Michael L.1,McKee Mark D.1,Seitzer Jessica1,Han Bo W.1,Soukamneuth Samantha1,Leonard John1,Sepp-Lorenzino Laura1,Clark Eliana D.1,Lebwohl David1ORCID,Cohn Danny M.1ORCID

Affiliation:

1. From Te Toka Tumai, Department of Immunology, Auckland City Hospital (H.J.L., K.L.), and the Department of Medicine, University of Auckland (H.J.L.) — both in Auckland, New Zealand; the Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam (R.S.P., L.M.F., D.M.C.); Cambridge University Hospitals, NHS Foundation Trust, Cambridge, United Kingdom (P.G.); and Intellia Therapeutics, Cambridge, MA (D.M., J.S.B., M.Y.S., A.G....

Funder

Intellia Therapeutics

Publisher

Massachusetts Medical Society

Subject

General Medicine

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