Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks

Author:

Banerji Aleena1,Riedl Marc A.2,Bernstein Jonathan A.3,Cicardi Marco4,Longhurst Hilary J.5,Zuraw Bruce L.2,Busse Paula J.6,Anderson John7,Magerl Markus8,Martinez-Saguer Inmaculada9,Davis-Lorton Mark10,Zanichelli Andrea4,Li H. Henry11,Craig Timothy12,Jacobs Joshua13,Johnston Douglas T.14,Shapiro Ralph15,Yang William H.16,Lumry William R.17,Manning Michael E.18,Schwartz Lawrence B.19,Shennak Mustafa20,Soteres Daniel21,Zaragoza-Urdaz Rafael H.22,Gierer Selina23,Smith Andrew M.24,Tachdjian Raffi25,Wedner H. James26,Hebert Jacques27,Rehman Syed M.28,Staubach Petra29,Schranz Jennifer30,Baptista Jovanna30,Nothaft Wolfram30,Maurer Marcus8,

Affiliation:

1. Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston

2. Division of Rheumatology, Allergy & Immunology, University of California, San Diego

3. Department of Internal Medicine/Allergy Section Cincinnati, University of Cincinnati College of Medicine, Cincinnati, Ohio

4. Department of Biomedical and Clinical Sciences, Luigi Sacco, University of Milan, ASST Fatebenefratelli Sacco, Milan, Italy

5. Barts Health NHS Trust, London, United Kingdom

6. Icahn School of Medicine at Mount Sinai, New York, New York

7. Clinical Research Center of Alabama, Birmingham

8. Department of Dermatology and Allergy, Dermatological Allergology, Charité—Universitätsmedizin Berlin, Berlin, Germany

9. Haemophilia Centre Rhine Main, Mörfelden-Walldorf, Germany

10. Rheumatology Allergy and Immunology, NYU Winthrop Hospital, Mineola, New York

11. Institute for Asthma and Allergy, Chevy Chase, Maryland

12. Department of Medicine and Pediatrics, Pennsylvania State University, Allergy, Asthma, and Immunology, Hershey

13. Allergy and Asthma Clinical Research, Walnut Creek, California

14. Clinical Research of Charlotte, Charlotte, North Carolina

15. Immunology Department, Midwest Immunology Clinic, Plymouth, Minnesota

16. Ottawa Allergy Research Corporation and University of Ottawa Medical School, Ottawa, Ontario, Canada

17. Allergy Asthma Research Associates Research Center, Dallas, Texas

18. Medical Research of Arizona, Scottsdale

19. Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Virginia Commonwealth University, Richmond

20. Triumpharma, Amman, Jordan

21. Asthma and Allergy Associates PC, Colorado Springs, Colorado

22. University of Puerto Rico School of Medicine, San Juan

23. Division of Allergy, Clinical Immunology & Rheumatology, University of Kansas Medical Center, Kansas City

24. Allergy Associates of Utah, Murray

25. AIRE Medical of Los Angeles, University of California, Los Angeles

26. Division of Allergy and Immunology, Washington University, St Louis, Missouri

27. Centre de Recherche Appliqué en Allergie de Québec, Quebec, Canada

28. Toledo Institute of Clinical Research, Toledo, Ohio

29. Department of Dermatology, University Medicine Mainz, Mainz, Germany

30. Shire, Lexington, Massachusetts

Publisher

American Medical Association (AMA)

Subject

General Medicine

Reference23 articles.

1. HAE pathophysiology and underlying mechanisms.;Zuraw;Clin Rev Allergy Immunol,2016

2. Hereditary angioedema.;Zuraw;N Engl J Med,2008

3. HAE update: epidemiology and burden of disease.;Bernstein;Allergy Asthma Proc,2013

4. The humanistic, societal, and pharmaco-economic burden of angioedema.;Longhurst;Clin Rev Allergy Immunol,2016

5. Burden of illness in hereditary angioedema: a conceptual model.;Bygum;Acta Derm Venereol,2015

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