1. From the Department of Epidemiology and Biostatistics, Erasmus University Medical School (I.M.S.v.H., D.E.G., A.H.), the Department of Internal Medicine I, University Hospital Dijkzigt (l.M.S.v.H., F.H.M.D., M.A.D.H.S.), and the Department of Internal Medicine, Zuiderziekenhuis (P.W. de L.), all in Rotterdam, the Netherlands. Address reprint requests to Dr. Grobbee at the Department of Epidemiology and Biostatistics, Erasmus University Medical School, P.O. Box 1738, 3000 DR Rotterdam, the Netherlands.