1. University Hospitals Coventry and Warwickshire NHS Trust, University Hospital, Clifford Bridge Road, Coventry CV2 2DX, UK.
2. Warwick Medical School, University of Warwick, Warwick Clinical Trials Unit, Coventry CV4 7AL, UK.
3. Warwick Medical School, University of Warwick, Division of Health Sciences, Coventry CV4 7AL, UK.