Development of an Automated Screen for Kv7.2 Potassium Channels and Discovery of a New Agonist Chemotype-Reference-Cited by-同舟云学术

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Development of an Automated Screen for Kv7.2 Potassium Channels and Discovery of a New Agonist Chemotype

Published:2022 Issue: Volume: Page:
ISSN:1556-5068
Container-title:SSRN Electronic Journal
language:en
Short-container-title:SSRN Journal

Author:

Hernandez Ciria C.,Tarfa Rahilla A.,Limcaoco Jose M. I.,Liu Ruiting,Mondal Pravat,Hill Clare,Duncan R. Keith,Tzounopoulos Thanos,Stephenson Corey R. J.,O’Meara Matthew J.,Wipf Peter

Publisher

Elsevier BV

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference28 articles.

1. Biophysics, pathophysiology, and pharmacology of ion channel gating pores;A Moreau;Front. Pharmacol,2014

2. Neuronal KCNQ potassium channels: Physiology and role in disease;T J Jentsch;Nat. Rev. Neurosci,2000

3. Discovery of HN37 as a potent and chemically stable antiepileptic drug candidate;Y.-M Zhang;J. Med. Chem,2021

4. Synthesis and pharmacological characterization of conformationally restricted retigabine analogues as novel neuronal Kv7 channel activators;C Ostacolo;J. Med. Chem,2020

5. In vitro and in vivo characterization of Lu AA41178: A novel, brain penetrant, pan-selective Kv7 potassium channel opener with efficacy in preclinical models of epileptic seizures and psychiatric disorders;M Grupe;Eur. J. Pharmacol,2020

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