Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators-Reference-Cited by-同舟云学术

Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators

Published:2019-12-09 Issue:1 Volume:63 Page:163-185
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ostacolo Carmine¹^ORCID,Miceli Francesco²,Di Sarno Veronica³,Nappi Piera²,Iraci Nunzio³^ORCID,Soldovieri Maria Virginia⁴,Ciaglia Tania³,Ambrosino Paolo⁵,Vestuto Vincenzo³,Lauritano Anna²,Musella Simona⁶,Pepe Giacomo³^ORCID,Basilicata Manuela Giovanna³,Manfra Michele⁷,Perinelli Diego Romano⁸,Novellino Ettore¹^ORCID,Bertamino Alessia³^ORCID,Gomez-Monterrey Isabel M.¹^ORCID,Campiglia Pietro³^ORCID,Taglialatela Maurizio²^ORCID

Affiliation:

1. Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy

2. Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, 80131 Naples, Italy

3. Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy

4. Department of Medicine and Health Science V. Tiberio, University of Molise, Via F. de Sanctis, 86100 Campobasso, Italy

5. Department of Science and Technology (DST), University of Sannio, Via Port’Arsa 11, 82100 Benevento, Italy

6. European Biomedical Research Center (EBRIS), Via Salvatore de Renzi, 3, 84125 Salerno, Salerno, Italy

7. Department of Science, University of Basilicata, Via dell’Ateneo Lucano 10, 85100 Potenza, Italy

8. School of Pharmacy, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Macerata, Italy

Funder

Fondazione Telethon

Ministero dell’Istruzione, dell’Università e della Ricerca

Università degli Studi di Napoli Federico II

Compagnia di San Paolo

Ministero della Salute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00796

Reference71 articles.

1. Early Identification of Refractory Epilepsy

2. Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels

3. Pharmacological Targeting of Neuronal Kv7.2/3 Channels: A Focus on Chemotypes and Receptor Sites

4. Modulation of KCNQ2/3 Potassium Channels by the Novel Anticonvulsant Retigabine

5. Atomic basis for therapeutic activation of neuronal potassium channels

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