Synthesis of 2-(Prop-2-ynyloxy) Benzaldehyde using Salicyl Aldehyde and Propargyl Bromide in Aqueous Micellar Media

Abstract

Abstract Advances in science and technology are promoting eco-friendly synthesis routes, green chemicals, and non-hazardous solvents. A suitable method for the synthesis of 2-(prop-2-ynyloxy) benzaldehyde was developed using three different aqueous micellar media. The targeted product ether is completely immiscible in water, but in combination with interface active surfactants it has been possible to produce the hydrophobic organic compound in water. Micelles function as a pseudocellular organic environment to isolate species from the main solvent and favor compartmentalization of reagents. There is an increase in the local concentration and consequently the reactivity increases. The use of such unique chemo-, regio-, and stereoselectivity renders this reaction new. Organic species added to a micellar media are distributed between water and micelles depending on polarity, charge, and size. In the experiments it was observed that salicylaldehyde and propargyl bromide interacted best in CTAB media and the yield of the formed product was 96 %.