Herpes simplex virus type 2 infection as a biomarker for sexual debut among young people in sub-Saharan Africa: a literature review-Reference-Cited by-同舟云学术

Herpes simplex virus type 2 infection as a biomarker for sexual debut among young people in sub-Saharan Africa: a literature review

Published:2012-11 Issue:11 Volume:23 Page:761-766
ISSN:0956-4624
Container-title:International Journal of STD & AIDS
language:en
Short-container-title:Int J STD AIDS

Author:

Bastien S¹,Mason-Jones A J²³,De Koker P³⁴,Mmbaga E J⁵,Ross D A⁶,Mathews C²³

Affiliation:

1. Institute for Basic Medical Sciences, Faculty of Medicine, University of Oslo, Domus Medica, Sognsvannsveien 9, 0372 Oslo, Norway

2. Health Systems Research Unit, Medical Research Council

3. Adolescent Health Research Unit, University of Cape Town, Cape Town, South Africa

4. International Center for Reproductive Health, Ghent University, Ghent, Belgium

5. Department of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

6. MRC Tropical Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK

Abstract

Biological markers are needed in order to provide objective measures to validate self-reported sexual behaviour and interpret prevention trial data. In this review, we evaluated herpes simplex type 2 virus (HSV-2), one of the most prevalent sexually transmitted infections in sub-Saharan Africa as a biological marker of sexual debut. Based on our findings, we do not recommend using HSV-2 as a biomarker for sexual debut due to its low transmission probabilities and the fact that HSV-2 prevalence is not 100% among potential sexual partners. We recommend that the validation of alternative biological measures should be prioritized, and included in future studies and trials of interventions to reduce sexual health risk.

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

Link

http://journals.sagepub.com/doi/pdf/10.1258/ijsa.2012.011433

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