Effect of Saccharina latissima Extract on the Antioxidant System Parameters of Rat Blood After Exposure to Carbendazim

Author:

Melnikova M. V.1,Kashuro V. A.2,Batotsyrenova E. G.3,Kubarskaya L. G.1,Zolotoverkhaia E. A.1,Kolbasova T. A.1,Vakunenkova O. A.1,Gladchuk A. S.1

Affiliation:

1. Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia

2. St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia; Herzen State Pedagogical University of Russia

3. Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia; St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia

Abstract

An experimental study of antioxidant parameters in rats after exposure to carbendazim was carried out to study the effect of their pharmacological correction by an intragastric administration of Saccharina latissima extract at a dose of 250 mg/kg for 14 days. The extract under study was found to reduce the activity of lipid peroxidation and promote the neutralization of hydrogen peroxide.

Publisher

Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency

Subject

General Medicine

Reference5 articles.

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2. Krasnov К.А., Gladchuk A.S., Alexandrova M.L., Keltsieva O.A., Zaytseva M.A., Melnikova M.V., Reinyuk V.L., Podolskaya E.P. Izuchenie sostava lipidnykh pigmentov belomorskoy vodorosli Saccharina latissima metodami TSKh i MALDI-MS [Study of the lipid pigment composition in the white sea algae Saccharina latissima using TLC and MALDI-MS]. Toksikologicheskij vestnik [Toxicological Review]. 2020;(5):50-56. (In Russian). DOI: 10.36946/08697922-2020-5-50-56.

3. Podosinovikova N.P., Krasnov К.А., Bondarenko A.A., Alexandrova M.L., Zaytseva M.A., Khalaman V.V. Izuchenie toksichnosti i bezopasnosti lipofil'nykh ekstraktov belomorskikh burykh vodorosley — fukusa puzyrchatogo i laminarii sakharistoy na modeli Daphnia magna Straus [Studying the toxicity and safety of the lipophilic extracts of belomorian brown algae — fucus vesiculosus and saccharina latissima on the Daphnia magna Straus model]. Toksikologicheskiy vestnik [Toxicological Review]. 2020;4:49-55. (In Russian). DOI: 10.36946/0869-7922-2020-4-49-55.

4. Muthuviveganandavel V., Muthuraman P., Muthu S., Srikumar K. Toxic effects of carbendazim at low dose levels in male rats. J. Toxicol. Sci. 2008;33(1):25-30. DOI: 10.2131/jts.33.25.

5. Selmanoglu G., Barlas N., Songur S., Ko^kaya E.A. Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats. Hum. Exp. Toxicol. 2001;20(12):625-630. DOI: 10.1191/096032701718890603.

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