Cell polarity: models and mechanisms from yeast, worms and flies

Author:

Thompson Barry J.1

Affiliation:

1. Cancer Research UK, London Research Institute, Lincoln’s Inn Fields, London WC2A 3LY, UK.

Abstract

Determinants of cell polarity orient the behaviour of many cell types during development. Pioneering genetic screens in yeast, worms and flies have identified key polarity determinants that are evolutionarily conserved across the animal kingdom. Recent work in these three model organisms has combined computer modelling with experimental analysis to reveal the molecular mechanisms that drive the polarisation of determinants. Two key principles have emerged: the first is the requirement for a positive-feedback loop to drive self-recruitment of determinants to the plasma membrane; the second is the requirement for mutual antagonism between determinants that localise to opposite ends of the cell.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

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