Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6–aPKC
Author:
Affiliation:
1. Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA
2. Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
Abstract
Publisher
The Company of Biologists
Subject
Cell Biology
Link
http://journals.biologists.com/jcs/article-pdf/120/18/3200/1370488/3200.pdf
Reference32 articles.
1. Aceto, D., Beers, M. and Kemphues, K. J. (2006). Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans. Dev. Biol.299, 386-397.
2. Albertson, R. and Doe, C. Q. (2003). Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat. Cell Biol.5, 166-170.
3. Barros, C. S., Phelps, C. B. and Brand, A. H. (2003). Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport. Dev. Cell5, 829-840.
4. Beers, M. and Kemphues, K. (2006). Depletion of the co-chaperone CDC-37 reveals two modes of PAR-6 cortical association in C. elegans embryos. Development133, 3745-3754.
5. Betschinger, J., Mechtler, K. and Knoblich, J. A. (2003). The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature422, 326-330.
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