Connecting theory and experiment in cell and tissue mechanics

Author:

Schwayer Cornelia1ORCID,Brückner David B.2ORCID

Affiliation:

1. Friedrich Miescher Institute for Biomedical Research 1 , Maulbeerstrasse 66, 4058 Basel , Switzerland

2. Institute of Science and Technology Austria 2 , Am Campus 1, 3400 Klosterneuburg , Austria

Abstract

ABSTRACT Understanding complex living systems, which are fundamentally constrained by physical phenomena, requires combining experimental data with theoretical physical and mathematical models. To develop such models, collaborations between experimental cell biologists and theoreticians are increasingly important but these two groups often face challenges achieving mutual understanding. To help navigate these challenges, this Perspective discusses different modelling approaches, including bottom-up hypothesis-driven and top-down data-driven models, and highlights their strengths and applications. Using cell mechanics as an example, we explore the integration of specific physical models with experimental data from the molecular, cellular and tissue level up to multiscale input. We also emphasize the importance of constraining model complexity and outline strategies for crosstalk between experimental design and model development. Furthermore, we highlight how physical models can provide conceptual insights and produce unifying and generalizable frameworks for biological phenomena. Overall, this Perspective aims to promote fruitful collaborations that advance our understanding of complex biological systems.

Funder

European Molecular Biology Organization

Human Frontier Science Program

NOMIS Foundation

Publisher

The Company of Biologists

Subject

Cell Biology

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