The Ena/VASP enigma-Reference-Cited by-同舟云学术

The Ena/VASP enigma

Published:2002-12-15 Issue:24 Volume:115 Page:4721-4726
ISSN:1477-9137
Container-title:Journal of Cell Science
language:en
Short-container-title:

Author:

Krause Matthias¹,Bear James E.¹,Loureiro Joseph J.¹,Gertler Frank B.¹

Affiliation:

1. Department of Biology, Massachusetts Institute of Technology, Cambridge,MA 02139-4307, USA

Abstract

Ena/VASP proteins are actin-binding proteins that localize to actin stress fibres, the tips of filopodia and the lamellipodial leading edge. In the past few years, a number of seemingly conflicting studies have confused the Ena/VASP field, pointing to roles for these proteins in both promotion and inhibition of actin-dependent processes. Recent discoveries resolve these contradictions and suggest a novel mechanism of Ena/VASP function, in which the proteins function as `anti-capping' proteins that antagonize capping proteins at the barbed end of actin filaments.

Publisher

The Company of Biologists

Subject

Cell Biology

Link

http://journals.biologists.com/jcs/article-pdf/115/24/4721/1480469/4721.pdf

Reference46 articles.

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