Directed differentiation of neural cells to hypothalamic dopaminergic neurons-Reference-Cited by-同舟云学术

Directed differentiation of neural cells to hypothalamic dopaminergic neurons

Published:2005-12-01 Issue:23 Volume:132 Page:5185-5197
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Ohyama Kyoji¹,Ellis Pamela¹,Kimura Shioko²,Placzek Marysia¹

Affiliation:

1. Department of Biomedical Science, University of Sheffield, Firth Court,Western Bank, Sheffield S10 2TN, UK

2. National Cancer Institute, National Institute of Health, MD, 20892, USA

Abstract

Hypothalamic neurons play a key role in homeostasis, yet little is known about their differentiation. Here, we demonstrate that Shh and Bmp7 from the adjacent prechordal mesoderm govern hypothalamic neural fate, their sequential action controlling hypothalamic dopaminergic neuron generation in a Six3-dependent manner. Our data suggest a temporal distinction in the requirement for the two signals. Shh acts early to specify dopaminergic neurotransmitter phenotype. Subsequently, Bmp7 acts on cells that are ventralised by Shh, establishing aspects of hypothalamic regional identity in late-differentiating/postmitotic cells. The concerted actions of Shh and Bmp7 can direct mouse embryonic stem cell-derived neural progenitor cells to a hypothalamic dopaminergic fate ex vivo.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/132/23/5185/1151732/5185.pdf

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