1. School of Mathematics and Statistics, University of Sheffield 1 , Hicks Building, Hounsfield Road, Sheffield S3 7RH , UK
2. School of Biosciences, University of Sheffield, Firth Court, Western Bank 2 , Sheffield S10 2TN , UK
3. School of Engineering and Informatics, University of Sussex 3 Department of Informatics , , Falmer, Brighton BN1 9RH , UK