Affiliation:
1. Department of Biology, University of Oklahoma, 730 Van Vleet Oval, Norman, OK 73019, USA
Abstract
ABSTRACT
Lampreys and hagfishes are the only surviving relicts of an ancient but ecologically dominant group of jawless fishes that evolved in the seas of the Cambrian era over half a billion years ago. Because of their phylogenetic position as the sister group to all other vertebrates (jawed vertebrates), comparisons of embryonic development between jawless and jawed vertebrates offers researchers in the field of evolutionary developmental biology the unique opportunity to address fundamental questions related to the nature of our earliest vertebrate ancestors. Here, we describe how genetic analysis of embryogenesis in the sea lamprey (Petromyzon marinus) has provided insight into the origin and evolution of developmental-genetic programs in vertebrates. We focus on recent work involving CRISPR/Cas9-mediated genome editing to study gene regulatory mechanisms involved in the development and evolution of neural crest cells and new cell types in the vertebrate nervous system, and transient transgenic assays that have been instrumental in dissecting the evolution of cis-regulatory control of gene expression in vertebrates. Finally, we discuss the broad potential for these functional genomic tools to address previously unanswerable questions related to the evolution of genomic regulatory mechanisms as well as issues related to invasive sea lamprey population control.
Publisher
The Company of Biologists
Subject
Insect Science,Molecular Biology,Animal Science and Zoology,Aquatic Science,Physiology,Ecology, Evolution, Behavior and Systematics
Reference215 articles.
1. Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse;Abu-Issa;Development,2002
2. Regulatory evolution of Tbx5 and the origin of paired appendages;Adachi;Proc. Natl. Acad. Sci. USA,2016
3. The Changing Role of the Embryo in Evolutionary Thought
4. Natural history of the sea lamprey, Petromyzon marinus in Michigan;Applegate;U.S. Fish Wildl. Serv. Spec. Sci. Rep-Wildl,1950
5. The sea lamprey;Applegate;Sci. Am.,1955
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献