Affiliation:
1. UC Davis School of Veterinary Medicine Department of Anatomy, Physiology, and Cell Biology , , 1089 Veterinary Medicine Drive, Davis, CA 95616 , USA
Abstract
ABSTRACT
Neural crest cells (NCCs) are a dynamic, multipotent, vertebrate-specific population of embryonic stem cells. These ectodermally-derived cells contribute to diverse tissue types in developing embryos including craniofacial bone and cartilage, the peripheral and enteric nervous systems and pigment cells, among a host of other cell types. Due to their contribution to a significant number of adult tissue types, the mechanisms that drive their formation, migration and differentiation are highly studied. NCCs have a unique ability to transition from tightly adherent epithelial cells to mesenchymal and migratory cells by altering their polarity, expression of cell-cell adhesion molecules and gaining invasive abilities. In this Review, we discuss classical and emerging factors driving NCC epithelial-to-mesenchymal transition and migration, highlighting the role of signaling and transcription factors, as well as novel modifying factors including chromatin remodelers, small RNAs and post-translational regulators, which control the availability and longevity of major NCC players.
Funder
School of Veterinary Medicine, University of California, Davis
National Science Foundation
University of California, Davis
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Cited by
13 articles.
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