New trends in cellular therapy-Reference-Cited by-同舟云学术

New trends in cellular therapy

Published:2020-09-15 Issue:18 Volume:147 Page:
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Okano Hideyuki¹²^ORCID,Sipp Doug¹²³⁴^ORCID

Affiliation:

1. Keio University School of Medicine, Department of Physiology, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan

2. Keio University Global Research Institute, 2-15-45 Mita, Minato-ku, Tokyo 108-8345, Japan

3. RIKEN Center for Developmental Biology, 2-2-3 Minatojima Minamimachi, Chuo-ku, Kobe 650-0047, Japan

4. RIKEN Center for Advanced Intelligence Project, Nihonbashi 1-chome Mitsui Building, 15th floor, 1-4-1 Nihonbashi, Chuo-ku, Tokyo 103-0027, Japan

Abstract

ABSTRACT Regenerative therapies, including both gene and cellular therapies, aim to induce regeneration of cells, tissues and organs and restore their functions. In this short Spotlight, we summarize the latest advances in cellular therapies using pluripotent stem cells (PSCs), highlighting the current status of clinical trials using induced (i)PSC-derived cells. We also discuss the different cellular products that might be used in clinical studies, and consider safety issues and other challenges in iPSC-based cell therapy.

Funder

Japan Agency for Medical Research and Development

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/doi/10.1242/dev.192567/1967019/dev192567.pdf

Reference68 articles.

1. MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates;Aron Badin;Nat. Commun.,2019

3. Human trials of stem cell-derived dopamine neurons for Parkinson's disease: dawn of a new era;Barker;Cell Stem Cell,2017

4. Islet cell replacement therapy for insulin-dependent diabetes;Cooper-Jones,2017