Author:
Bernkopf Dominic B.,Hadjihannas Michel V.,Behrens Jürgen
Abstract
Axin and conductin/axin2 are structurally related inhibitors of Wnt/β-catenin signalling that promote degradation of β-catenin. Whereas axin is constitutively expressed, conductin is a Wnt target gene implicated in negative feedback regulation. Here we show that axin and conductin differ in their functional interaction with the upstream Wnt pathway component Dvl. Conductin shows reduced binding to Dvl2 compared to axin, and degradation of β-catenin by conductin is only poorly blocked by Dvl2. We propose that insensitivity to Dvl is an important feature of conductin's role as a negative feedback regulator of Wnt signalling.
Publisher
The Company of Biologists
Cited by
42 articles.
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