Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β-Reference-Cited by-同舟云学术

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

Published:1998-04-24 Issue:5363 Volume:280 Page:596-599
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Behrens Jürgen¹²,Jerchow Boris-Alexander¹²,Würtele Martin¹²,Grimm Jan¹²,Asbrand Christian¹²,Wirtz Ralph¹²,Kühl Michael¹²,Wedlich Doris¹²,Birchmeier Walter¹²

Affiliation:

1. J. Behrens, B.-A. Jerchow, M. Würtele, J. Grimm, C. Asbrand, R. Wirtz, W. Birchmeier, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13122 Berlin, Germany.

2. M. Kühl and D. Wedlich, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

Abstract

Control of stability of β-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both β-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC). Conductin induced β-catenin degradation, whereas mutants of conductin that were deficient in complex formation stabilized β-catenin. Fragments of APC that contained a conductin-binding domain also blocked β-catenin degradation. Thus, conductin is a component of the multiprotein complex that directs β-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference27 articles.

1. Hülsken J., Birchmeier W., Behrens J., J. Cell Biol.127, 2061 (1994).

2. Aberle H., et al., J. Cell Sci.107, 3655 (1994).

3. WNTs modulate cell fate and behavior during vertebrate development

4. Peifer M., Trends Cell Biol.5, 224 (1995).

5. β-catenin is a target for the ubiquitin–proteasome pathway

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