1. German Federal Institute for Risk Assessment, German Centre for the Protection of Laboratory Animals (Bf3R) 1 , 10589 Berlin , Germany
2. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health 2 , 10117 Berlin , Germany
3. Berlin Institute of Health at Charité - Universitätsmedizin Berlin 3 , 10178 Berlin , Germany