Testing developmental toxicity in a second species: are the differences due to species or replication error?

Author:

Braakhuis Hedwig M.,Theunissen Peter T.,Slob Wout,Rorije Emiel,Piersma Aldert H.

Funder

Dutch Government Funding

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference20 articles.

1. Dose-Response Assessment for Developmental toxicity. II. Comparison of generic benchmark dose estimates with no observed adverse effect levels;Allen;Fundam. Appl. Toxicol.,1994

2. Deriving a data-based interspecies assessment factor using the NOAEL and the benchmark dose approach;Bokkers;Crit. Rev. Toxicol.,2007

3. Interspecies differences in toxicokinetics: an evaluation of historical data and the consequences for the interspecies assessment factor. Extrapolation in human health hazard characterization: a probabilistic approach. Utrecht;Bokkers,2009

4. Guidance on Information Requirements and Chemical Safety Assessment Chapter R.8: Characterisation of Dose [concentration]-Response for Human Health;ECHA,2012

5. Update: use of the benchmark dose approach in risk assessment

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