Affiliation:
1. Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA
Abstract
The Rho-family proteins make up a major branch of the Ras superfamily of small GTPases. To date, 22 human genes encoding at least 25 proteins have been described. The best known `classical' members are RhoA, Rac1 and Cdc42. Highly related isoforms of these three proteins have not been studied as intensively, in part because it has been assumed that they are functionally identical to their better-studied counterparts. This now appears not to be the case. Variations in C-terminal-signaled modifications and subcellular targeting cause otherwise highly biochemically related isoforms (e.g. RhoA, RhoB and RhoC) to exhibit surprisingly divergent biological activities. Whereas the classical Rho GTPases are regulated by GDP/GTP cycling, other Rho GTPases are also regulated by other mechanisms, particularly by transcriptional regulation. Newer members of the family possess additional sequence elements beyond the GTPase domain, which suggests they exhibit yet other mechanisms of regulation.
Publisher
The Company of Biologists
Reference123 articles.
1. Abe, T., Kato, M., Miki, H., Takenawa, T. and Endo, T. (2003). Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth. J. Cell Sci.116, 155-168.
2. Adamson, P., Paterson, H. F. and Hall, A. (1992a). Intracellular localization of the P21rho proteins. J. Cell Biol.119, 617-627.
3. Adamson, P., Marshall, C. J., Hall, A. and Tilbrook, P. A. (1992b). Post-translational modifications of p21rho proteins. J. Biol. Chem.267, 20033-20038.
4. Adnane, J., Muro-Cacho, C., Mathews, L., Sebti, S. M. and Munoz-Antonia, T. (2002). Suppression of rho B expression in invasive carcinoma from head and neck cancer patients. Clin. Cancer Res.8, 2225-2232.
5. Adra, C. N., Manor, D., Ko, J. L., Zhu, S., Horiuchi, T., van Aelst, L., Cerione, R. A. and Lim, B. (1997). RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. Proc. Natl. Acad. Sci. USA94, 4279-4284.
Cited by
500 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献