1. Cardiovascular Research Center, Lifespan Cardiovascular Institute, Rhode Island Hospital, Department of Medicine, Division of Cardiology, Alpert Medical School of Brown University, Providence 1 , RI 02903 , USA
2. Centre for Cancer Biology, an alliance between SA Pathology and the University of South Australia 2 , Adelaide 5000 , Australia
3. Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide 3 , Adelaide 5000 , Australia
4. Toronto Metropolitan University 4 Department of Chemistry and Biology , , Toronto, Ontario , M5B 2K3 Canada