Author:
Chen De-Xin,Lu Chuang-Hong,Na Na,Yin Rui-Xing,Huang Feng
Abstract
AbstractCardiovascular diseases (CVDs) have emerged as a predominant threat to human health, surpassing the incidence and mortality rates of neoplastic diseases. Extracellular vesicles (EVs) serve as vital mediators in intercellular communication and material exchange. Endothelial progenitor cells (EPCs), recognized as precursors of vascular endothelial cells (ECs), have garnered considerable attention in recent years due to the potential therapeutic value of their derived extracellular vesicles (EPC-EVs) in the context of CVDs. This comprehensive review systematically explores the origins, characteristics, and functions of EPCs, alongside the classification, properties, biogenesis, and extraction techniques of EVs, with particular emphasis on their protective roles in CVDs. Additionally, we delve into the essential bioactive components of EPC-EVs, including microRNAs, long non-coding RNAs, and proteins, analyzing their beneficial effects in promoting angiogenesis, anti-inflammatory and anti-oxidant activities, anti-fibrosis, anti-apoptosis, and myocardial regeneration. Furthermore, this review comprehensively investigates the therapeutic potential of EPC-EVs across various CVDs, encompassing acute myocardial infarction, myocardial ischemia–reperfusion injury, atherosclerosis, non-ischemic cardiomyopathies, and diabetic cardiovascular disease. Lastly, we summarize the potential challenges associated with the clinical application of EPC-EVs and outline future directions, aiming to offer a valuable resource for both theoretical insights and practical applications of EPC-EVs in managing CVDs.
Funder
National Natural Science Foundation of China
Guangxi Key Laboratory of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention
Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases
Innovative Research Group Project of the National Natural Science Foundation of China
‘139’ Plan for Training High-level Medical Talents of Guangxi
Innovation Project of Guangxi Graduate Education
Open subject of Guangxi Key Laboratory of Precision Medicine for Cardiovascular and Cerebrovascular Disease Prevention and Treatment
Clinical Research Climbing Program of the First Affiliated Hospital of Guangxi Medical University
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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