How to make a primordial germ cell-Reference-Cited by-同舟云学术

How to make a primordial germ cell

Published:2014-01-15 Issue:2 Volume:141 Page:245-252
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Magnúsdóttir Erna¹²³⁴,Surani M. Azim¹²³

Affiliation:

1. Wellcome Trust, Cancer Research UK, Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK.

2. Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.

3. Wellcome Trust-Medical Research Council, Stem Cell Institute, University of Cambridge, University of Cambridge, Cambridge CB2 3DY, UK.

4. Department of Biochemistry and Molecular Biology, University of Iceland, Vatnsmyrarvegi 16, 101 Reykjavík, Iceland.

Abstract

Primordial germ cells (PGCs) are the precursors of sperm and eggs, which generate a new organism that is capable of creating endless new generations through germ cells. PGCs are specified during early mammalian postimplantation development, and are uniquely programmed for transmission of genetic and epigenetic information to subsequent generations. In this Primer, we summarise the establishment of the fundamental principles of PGC specification during early development and discuss how it is now possible to make mouse PGCs from pluripotent embryonic stem cells, and indeed somatic cells if they are first rendered pluripotent in culture.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/141/2/245/1322284/245.pdf

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