Notch signaling: control of cell communication and cell fate-Reference-Cited by-同舟云学术

Notch signaling: control of cell communication and cell fate

Published:2004-03-01 Issue:5 Volume:131 Page:965-973
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Lai Eric C.¹

Affiliation:

1. Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA e-mail: lai@fruitfly.org

Abstract

Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/131/5/965/1149209/965.pdf

Reference61 articles.

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3. Axelrod, J. D., Matsuno, K., Artavanis-Tsakonas, S. and Perrimon, N. (1996). Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science271,1826-1832.

4. Bailey, A. M. and Posakony, J. W. (1995). Suppressor of Hairless directly activates transcription of Enhancer of split Complex genes in response to Notch receptor activity. Genes Dev.9,2609-2622.

5. Barolo, S. and Posakony, J. W. (2002). Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling. Genes Dev.16,1167-1181.

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