Affiliation:
1. Department of Bioengineering University of Washington Seattle Washington USA
2. Environmental Molecular Sciences Laboratory Pacific Northwest National Laboratory Richland Washington USA
Abstract
AbstractDesign patterns are generalized solutions to frequently recurring problems. They were initially developed by architects and computer scientists to create a higher level of abstraction for their designs. Here, we extend these concepts to cell biology to lend a new perspective on the evolved designs of cells' underlying reaction networks. We present a catalog of 21 design patterns divided into three categories: creational patterns describe processes that build the cell, structural patterns describe the layouts of reaction networks, and behavioral patterns describe reaction network function. Applying this pattern language to the E. coli central metabolic reaction network, the yeast pheromone response signaling network, and other examples lends new insights into these systems.
Funder
Division of Cancer Prevention, National Cancer Institute
Subject
General Biochemistry, Genetics and Molecular Biology
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