Advances in live imaging early mouse development: exploring the researcher's interdisciplinary toolkit

Author:

Stower Matthew J.1,Srinivas Shankar1ORCID

Affiliation:

1. Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK

Abstract

ABSTRACT Live imaging is an important part of the developmental biologist's armoury of methods. In the case of the mouse embryo, recent advances in several disciplines including embryo culture, microscopy hardware and computational analysis have all contributed to our ability to probe dynamic events during early development. Together, these advances have provided us with a versatile and powerful ‘toolkit’, enabling us not only to image events during mouse embryogenesis, but also to intervene with them. In this short Spotlight article, we summarise advances and challenges in using live imaging specifically for understanding early mouse embryogenesis.

Funder

Wellcome Trust

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

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