PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization-Reference-Cited by-同舟云学术

PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization

Published:2005-07-15 Issue:14 Volume:132 Page:3281-3291
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Yue Qing¹,Groszer Matthias¹,Gil Jose S.²,Berk Arnold J.²³,Messing Albee⁴,Wu Hong¹²,Liu Xin¹²⁵

Affiliation:

1. Department of Molecular and Medical Pharmacology, University of California,Los Angeles, CA 90095, USA

2. Molecular Biology Institute, University of California, Los Angeles, CA 90095,USA

3. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA

4. Department of Pathobiological Sciences and Waisman Center, University of Wisconsin, Madison, WI 53705, USA

5. Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA

Abstract

Development of the central nervous system is controlled by both intrinsic and extrinsic signals that guide neuronal migration to form laminae. Although defects in neuronal mobility have been well documented as a mechanism for abnormal laminar formation, the role of radial glia, which provide the environmental cues, in modulating neuronal migration is less clear. We provide evidence that loss of PTEN in Bergmann glia leads to premature differentiation of this crucial cell population and subsequently to extensive layering defects. Accordingly, severe granule neuron migration defects and abnormal laminar formation are observed. These results uncover an unexpected role for PTEN in regulating Bergmann glia differentiation, as well as the importance of time-dependent Bergmann glia differentiation during cerebellar development.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/132/14/3281/1509531/3281.pdf

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