Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt-Reference-Cited by-同舟云学术

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

Published:1997-01-31 Issue:5300 Volume:275 Page:661-665
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Dudek Henryk¹,Datta Sandeep Robert¹,Franke Thomas F.²,Birnbaum Morris J.³,Yao Ryoji⁴,Cooper Geoffrey M.⁴,Segal Rosalind A.⁵,Kaplan David R.⁶,Greenberg Michael E.¹

Affiliation:

1. H. Dudek, S. R. Datta, M. E. Greenberg, Division of Neuroscience, Department of Neurology, Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

2. T. F. Franke, Montreal Neurological Institute, McGill University, PQ H3A 2B4, Canada; and Division of Signal Transduction, Beth Israel Hospital, and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

3. M. J. Birnbaum, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

4. R. Yao and G. M. Cooper, Division of Molecular Genetics, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

5. R. A. Segal, Department of Neurology, Beth Israel Hospital, and Harvard Medical School, Boston, MA 02115, USA.

6. D. R. Kaplan, Montreal Neurological Institute, McGill University, PQ H3A 2B4, Canada.

Abstract

A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-K) triggered the activation of two protein kinases, the serine-threonine kinase Akt and the p70 ribosomal protein S6 kinase (p70 S6K ). Experiments with pharmacological inhibitors, as well as expression of wild-type and dominant-inhibitory forms of Akt, demonstrated that Akt but not p70 S6K mediates PI3-K-dependent survival. These findings suggest that in the developing nervous system, Akt is a critical mediator of growth factor-induced neuronal survival.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference49 articles.

1. Borasio G. D., et al., Neuron 2, 1087 (1989);

2. Nobes C. D. , Reppas J. B. , Markus A. , Tolkovsky A. M., Neuroscience 70, 1067 (1996).

3. Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

4. Yao R., Cooper G. M., ibid. 267, 2003 (1995).

5. Yao R., Cooper G. M., Oncogene 13, 343 (1996).

Cited by 2232 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Molecular mechanisms of immune rejection against xenotransplantation in the pearl oyster Pinctada fucata revealed by serum proteomics;Aquaculture;2025-01

2. Insulin-Like Growth Factor Signaling in Alzheimer’s Disease: Pathophysiology and Therapeutic Strategies;Molecular Neurobiology;2024-09-06

3. Brain incoming call from glia during neuroinflammation: Roles of extracellular vesicles;Neurobiology of Disease;2024-09

4. Deciphering the Akt1-HuD interaction in HuD-mediated neuronal differentiation;Biochimie;2024-06

5. Systemic mechanism of Panax noteginseng saponins in antiaging based on network pharmacology combined with experimental validation;Ibrain;2024-06