ChatGPT is shaking up the higher education world by generating informative content that mimics human writing. However, its integration into university settings raises concerns about academic integrity and potential information security risks. The aim of this study is to systematically review the impact of using ChatGPT in university settings and its implications for higher education. This study employed a systematic review method to assess the evidence in the literature. Thirty-nine articles were analyzed according to PRISMA principles. The findings suggest that ChatGPT has the potential to personalize learning and improve writing performance. However, there are still potential issues, such as undermining academic integrity and breaching personal information. Therefore, urgent action is needed to address these issues and optimize the use of ChatGPT in higher education. Future research could further discuss how to fully utilize ChatGPT in academia while carefully considering ethical issues.