This study aims to determine the readiness and adoption scenario in Pharmaceutical Component Manufacturing (PCM) industry, particularly the SMEs based in Europe. A quantitative survey of 434 PCM SMEs from around Europe was conducted. At the same time, organizations' preparedness was assessed using key performance indicators (KPIs), and their adoption status was determined by the challenges they encountered while adopting lean and their perceived advantages. The principal component analysis and multivariate analysis of the hypotheses revealed gaps in KPIs in these businesses and significant barriers to achieving desired goals. Based on the findings, a framework that shows these companies how to be efficient was proposed. This framework includes using tools and practices to find and eliminate waste, optimize work, and enhance employee productivity. It also emphasized the permanency of continuous improvement, applying relevant tools, and employee empowerment.