The new ruthenium(II)-bipyridyl complex with O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate: Synthesis and characterization

Abstract

<p>The new bipyridyl complex of ruthenium(II) with <em>O,O'</em>-diethyl-(<em>S,S</em>)-ethylenediamine-<em>N,N'</em>-di-2-(3-cyclohexyl)propanoate was synthesized. The reaction of <em>cis</em>-[RuCl₂(bpy)₂]<em> </em>and ligand was performed in water/ethanol solution, in the presence of lithium hydroxide, under reflux. The addition of ammonium hexafluorophosphate, complex was precipitated. The complex, <em>cis</em>-[Ru(bpy)₂L](PF₆)₂, was characterized by ¹H and ¹³C NMR, UV-Vis, IR spectroscopy, ESI-MS spectrometry and elemental analysis. Results indicate an octahedral geometry of the complex, with <em>N,N'</em>-coordinated <em>O,O'</em>-diethyl-(<em>S,S</em>)-ethylenediamine-<em>N,N'</em>-di-2-(3-cyclohexyl)propanoate. Complexes of this type are particularly important in terms of potential cytotoxicity and application in photodynamic therapy. Using this therapy, many side effects can be reduced and this may allow administration of higher dosages drugs.</p>