New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity-Reference-Cited by-同舟云学术

New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity

Published:2017 Issue:3 Volume:82 Page:267-275
ISSN:0352-5139
Container-title:Journal of the Serbian Chemical Society
language:en
Short-container-title:JSCS

Author:

Baroud Afya¹,Mihajlovic-Lalic Ljiljana²,Stankovic Dalibor³^ORCID,Kajzerberger Marijana⁴,Van Hecke⁵,Grguric-Sipka Sanja¹^ORCID,Savic Aleksandar¹^ORCID

Affiliation:

1. Faculty of Chemistry, Belgrade

2. Innovation Center of the Faculty of Chemistry, Belgrade

3. Innovation Center of the Faculty of Chemistry, Belgrade + The Vinča Institute of Nuclear Sciences, Belgrade

4. Institute for Oncology and Radiology of Serbia, Belgrade

5. Ghent University, Department of Inorganic and Physical Chemistry, XStruct, Ghent, Belgium

Abstract

A new Ru(II) bipyridyl complex with O4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were > 300 and 177.63?2.28 ?M for the A549 and K562 cells, respectively.

Funder

Ministry of Education, Science and Technological Development of the Republic of Serbia

Publisher

National Library of Serbia

Subject

General Chemistry

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