Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy-Reference-Cited by-同舟云学术

Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy

Published:2021-08 Issue:7 Volume:7 Page:
ISSN:2056-5623
Container-title:Future Science OA
language:en
Short-container-title:Future Science OA

Author:

Ferro Matteo¹^ORCID,Babă Dragoş-Florin²³,Cobelli Ottavio de¹⁴,Musi Gennaro¹⁴,Lucarelli Giuseppe⁵,Terracciano Daniela⁶,Porreca Angelo⁷,Busetto Gian Maria⁸,Giudice Francesco Del⁸,Soria Francesco⁹,Gontero Paolo⁹,Cantiello Francesco¹⁰,Damiano Rocco¹⁰,Rocco Papalia¹¹,Scarpa Roberto Mario¹¹,Abu Farhan Abdal Rahman¹⁰,Autorino Riccardo¹²,Brescia Antonio¹,Marchioni Michele¹³,Mari Andrea¹⁴,Minervini Andrea¹⁴,Longo Nicola¹⁵,Chiancone Francesco¹⁶^ORCID,Perdona’ Sisto¹⁷,Barone Biagio¹⁵,Placido Pietro De¹⁸,Catellani Michele¹,Bottero Danilo¹,Ditonno Pasquale⁵,Battaglia Michele⁵,Zamboni Stefania¹⁹,Antonelli Alessandro¹⁹²⁰,Greco Francesco²¹,Russo Giorgio Ivan²²,Smelzo Salvatore²³,Hurle Rodolfo²⁴,Crisan Nicolae²⁵,Manfredi Matteo²⁶,Porpiglia Francesco²⁶,Crocetto Felice¹⁵,Buonerba Carlo²⁷²⁸,Danilesco Alina²,Vartolomei Mihai Dorin¹²²⁹

Affiliation:

1. Department of Urology, European Institute of Oncology, IRCSS, Milan, Italy

2. Department of Cell & Molecular Biology, University of Medicine and Pharmacy, Targu Mures, Romania

3. Cardiovascular Disease and Transplant Institute, Department of Urology, Targu Mures, Romania

4. Department of Oncology & Haematology-Oncology, University of Milan, Milan, Italy

5. Department of Emergency & Organ Transplantation-Urology, Andrology & Kidney Transplantation Unit, University of Bari, Bari, Italy

6. Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy

7. Department of Oncological Urology, Veneto Institute of Oncology IOV, IRCSS, Padua, Italy

8. Department of Urology, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, Rome, Italy

9. Division of Urology, Department of Surgical Sciences, AOU Citta´ della Salute e della Scienza, Turin School of Medicine, Turin, Italy

10. Department of Urology, University of Catanzaro, Università ‘Magna Græcia’, Catanzaro, Italy

11. Department of Urology, Policlinic University Campus of Bio-Medicine of Rome, Rome, Italy

12. Division of Urology, Virginia Commonwealth University Health System, Richmond, VA 23298, USA

13. Department of Medical, Oral & Biotechnological Sciences, Gabriele d'Annunzio University of Chieti & Pescara, Chieti, Italy

14. Department of Experimental and Clinical Medicine, Unit of Oncologic Minimally-Invasive Urology and Andrology, University of Florence, Careggi University Hospital, Florence, Italy

15. Department of Neurosciences, Human Reproduction & Odontostomatology, University of Naples Federico II, Naples, Italy

16. Urology Unit, AORN Cardarelli, Naples, Italy

17. Division of Urology, National Cancer Institute IRCCS Pascale Foundation, Naples, Italy

18. Department of Clinical Medicine & Surgery, University of Naples Federico II, Naples, Italy

19. Department of Urology, ASST Spedali Civili di Brescia, Brescia, Italy

20. Department of Urology, University of Verona, Verona, Italy

21. Clinic of Urology, Centro Salute Uomo, Bergamo, Italy

22. Department of Urology, University of Catania, Catania, Italy

23. Department of Urology, San Raffaele Turro Hospital, San Raffaele University, Milan, Italy

24. Department of Urology, IRCCS Humanitas Research Hospital, Rozzano, Italy

25. Department of Urology, University of Medicine & Pharmacy Iuliu Haţieganu, Cluj-Napoca, Romania

26. Urology Unit - Department of Oncology, School of Medicine, University of Turin, Turin, Italy

27. Department of Oncology & Hematology, Regional Reference Center for Rare Tumors, University of Naples Federico II, Naples, Italy

28. National Reference Center for Environmental Health, Zoo-prophylactic Institute of Southern Italy, Portici, Italy

29. Department of Urology, Medical University of Vienna, Wien, Austria

Abstract

Aim: To investigate the prognostic role of neutrophil percentage-to-albumin ratio (NPAR) in muscle-invasive bladder cancer (MIBC) patients treated with neoadjuvant chemotherapy (NAC) and radical cystectomy (RC). Patients & methods: 213 patients were included. Inclusion criteria: Nonmetastatic, MIBC (cT2-T4aN0M0), at least three cycles of NAC, undergone RC and with blood count within 30 days before NAC. Results: Five-years overall survival (OS) with NPAR >18 was 34.06% (95% CI: 18.3–50.5) and 65.37% (95% CI: 52.4–75.6) with NPAR <18. Five years cancer-specific survival (CSS) with NPAR >18 was 42.9% (95% CI: 23.9–60.7) and 74.5% (95% CI: 62.6–83.1) with NPAR <18 (p < 0.001). In multivariable analysis, NPAR increased OS of 1.3 points and CSS of 4.37 points. Conclusion: High NPAR prior to NAC seems to be a strong predictor of OS and CSS in MIBC patients treated with NAC and RC.

Publisher

Future Science Ltd

Subject

Biotechnology

Link

https://www.future-science.com/doi/pdf/10.2144/fsoa-2021-0008

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