Çocukluk Çağı Metabolik Disfonksiyonla İlişkili Steatotik Karaciğer Hastalığında Hematolojik Biyobelirteçlerin Değerlendirilmesi

Abstract

Aim:We aimed to investigate the clinical significance and diagnostic value of inflammation-based biomarkers in children with a diagnosis of Metabolic Dysfunction Associated Steatotic Liver Disease(MASLD). Methods:This study was carried out by retrospectively evaluating the files of patients followed up in the Department of Pediatric Hepatology at xxUniversity between July 2022 and January 2023.The study was completed with 120 patients with MASLD diagnosed according to the criteria of the AASLD and EASL, 80 healthy controls.Comparisons were made by calculating laboratory values and formulas through them. Results:There were 50(41.7%)girls and 70(58.3%)boys in the patient group,and 40 girls (50.0%) and 40 boys(50.0%) in the control group.While 80 patients with Grade 0 detected in liver ultrasonography were taken as the control group;102(85%) Grade 1 and 18(15%)Grade 2-3 patients were considered as the patient group.The values of the patients were compared with the values of healthy volunteers.When the WBC, neutrophil, lymphocyte, platelet, MHR, RPR, RLR, MPR, WMR, GPR, SII and FIB-4score values were compared according to liver grading, a correlation was found in the tests performed on the patients. Conclusion:Our study suggests that the presence of MASLD should be investigated in individuals, and possible complications can be prevented with early diagnosis and treatment approaches.As a result, we think that the use of hematological biomarkers will be useful for the simple and rapid detection of patients with suspected MASLD and who need further examination and treatment.