Author:
Maha Abu Hajleh,Emad A.S Al-Dujaili, ,
Abstract
Hydrophobic ion-pairing (HIP) complexation technique has been displayed to modify the physicochemical properties, solubility, oral absorption, bioavailability, and the lipophilicity of an ionic drug in the lipid phase. This could affect a higher permeation through biological membranes. HIP complexation was considered through the formation of a neutral molecule by electrostatic interaction of ionizable groups of drugs with oppositely charged functional groups of a complex-forming agent. Subsequently, this ion-pair may encapsulate into many delivery systems. The objective of this manuscript was to study the effectiveness of ion-pair complextion and cover the update application of this strategy through several routes of administration such as ocular, oral, pulmonary, transdermal, and parenteral.
Publisher
Indian Drug Manufacturers' Association (IDMA)
Subject
Drug Discovery,Pharmaceutical Science,Pharmacology
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