ATTENUATION OF SALT INDUCED CARDIAC REMODELING BY GARCINIA INDICA FRUIT EXTRACT IN RATS

Abstract

The purpose of this study was to assess the impact of hydroalcoholic extract of Garcinia indica fruit on salt-induced cardiac remodeling in Sprague Dawley rats. Animals were fed with feed consisting of extra salt i.e. 2 %, 4 %, and 6 % w/w for 1,2,3 weeks respectively and 8 % w/w from 4th to 6th week; water was supplemented throughout the study with normal saline of 0.9% w/V. ECG was recorded weekly for assessing modifications in the heart function. Animals were sacrificed to obtain blood samples at the end of the study, which were centrifuged to obtain the serum to estimate various biochemical parameters including antioxidant biomarkers in the heart. G. indica treatment at a dosage of 200, 400, and 800mg/ kg showed significantly reduced dose-dependent in heart rate, QRS complex, RR-interval, and CK-MB. It also showed a significant increase in antioxidant biomarkers viz. compared with untreated group SOD, GSH, and CAT. The experimental result underscored G.indica's antioxidant and cardioprotective effects on cardiac remodeling.