EVALUATION OF ANTINEPHROLITHIATIC ACTIVITY OF MALLOTUS PHILIPPINENSIS LINN. IN RATS-Reference-Cited by-同舟云学术

EVALUATION OF ANTINEPHROLITHIATIC ACTIVITY OF MALLOTUS PHILIPPINENSIS LINN. IN RATS

Published:2017-09-28 Issue:09 Volume:54 Page:77-82
ISSN:0019-462X
Container-title:INDIAN DRUGS
language:en
Short-container-title:IND. DRU.

Author:

Shah S. K.,Patel K. R,Patel T. V.,Patel T. B.,

Abstract

The present study was aimed to evaluate antinephrolithiatic activity of alcoholic extract of Mallotus philippinensis Linn. on ethylene glycol (0.75% V/V) induced nephrolithiasis in rat model. The leaves of Mallotus philippinensis Linn. were extracted and antinephrolithiatic activity was evaluated at the dose of 250 & 500 mg/kg b.w., p.o. Treatment with alcoholic leaves extract of Mallotus philippinensis decreased levels of calcium oxalate, phosphate in urine and kidney homogenate. Serum levels of creatinine, urea and uric acid were also decreased significantly in curative as well as protective group as compared to model control rats. The alcoholic extract of Mallotus philippinensis Linn. at the dose of 500 mg/kg showed no microcrystalline deposition and kidney damage which enables us to confirm the protective and curative potential of Mallotus philippinensis Linn. on ethylene glycol induced nephrolithiasis in rats. It can be concluded that alcoholic leaves extract of Mallotus philippinensis possess a significant antinephrolithiatic activity.

Publisher

Indian Drug Manufacturers' Association (IDMA)

Subject

Drug Discovery,Pharmaceutical Science,Pharmacology

Reference21 articles.

1. 1. Ramachandran S, Vijayakumar TM.: Antilithiatic Activity of Poly Herbal Extracts on Ethylene glycol Induced Lithasis in Rats, Euro. J. of Biol. Sci, 2011, 3(2), 36-39.

2. 2. Baheti DG and Kadam SS.: Antiurolithiatic activity of a polyherbal formulation against calcium oxalate induced urolithiasis in rats, J. Adv. Pharm. Edu. & Res, 2013, 03, 61-71.

3. 3. Patel TB, Shah SK and Patel J.: Evaluation of antiurolithiatic activity of Chlorophytum borivilianum extract using experimental animals, Int J Ayu Pharm Chem, 2014, 01,132-42.

4. 4. Baumann JM.: Stone prevention; why so little progress, Uro. Res, 2002, 26, 77-81.

5. 5. Elhan M, Ergene B, Süntar I, Ozbilgin S, ÇitoLlu G, Demirel MA.: Preclinical Evaluation of Antiurolithiatic Activity of Viburnum opulus L. on Sodium Oxalate-Induced Urolithiasis Rat Model, Evidence-Based Complementary and Alternative Medicine, 2014, 1-10.