A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children

Author:

Brussee Janneke M.ORCID,Krekels Elke H. J.,Calvier Elisa A. M.,Palić Semra,Rostami-Hodjegan Amin,Danhof Meindert,Barrett Jeffrey S.,de Wildt Saskia N.,Knibbe Catherijne A. J.

Funder

Leiden University

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Reference83 articles.

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2. FDA. General Clinical pharmacology considerations for pediatric studies for drugs and biological products, guidance for industry, 2014. Available from: https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM425885.pdf .Accessed December 2017

3. Zisowsky J, Krause A, Dingemanse J. Drug development for pediatric populations: regulatory aspects. Pharmaceutics. 2010;2(4):364–88.

4. Krekels EH, Neely M, Panoilia E, Tibboel D, Capparelli E, Danhof M, et al. From pediatric covariate model to semiphysiological function for maturation: part I-extrapolation of a covariate model from morphine to zidovudine. CPT Pharmacometrics Syst Pharmacol. 2012;1:e9.

5. Zhao W, Biran V, Jacqz-Aigrain E. Amikacin maturation model as a marker of renal maturation to predict glomerular filtration rate and vancomycin clearance in neonates. Clin Pharmacokinet. 2013;52(12):1127–34.

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