From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part I-Extrapolation of a Covariate Model From Morphine to Zidovudine

Author:

Krekels EHJ12,Neely M3,Panoilia E14,Tibboel D2,Capparelli E5,Danhof M1,Mirochnick M6,Knibbe CAJ127

Affiliation:

1. Division of Pharmacology, Leiden; Amsterdam Center for Drug Research; Leiden The Netherlands

2. Department of Pediatric Intensive Care and Pediatric Surgery; Erasmus MC-Sophia Children's Hospital, Intensive Care and Department of Pediatric Surgery; Rotterdam The Netherlands

3. LAC/USC Medical Center; University of Southern California, LAC/USC Medical Center; Los Angeles California USA

4. Laboratory of Pharmacokinetics, University of Patras, Laboratory of Pharmacokinetics; Patras Greece

5. Department of Pediatrics; UC San Diego; La Jolla California USA

6. Division of Neonatology; Boston University; Boston Massachusetts USA

7. Department of Clinical Pharmacy; St. Antonius Hospital; Nieuwegein The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

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