Meeting Report: Metabolites in Safety Testing (MIST) Symposium—Safety Assessment of Human Metabolites: What’s REALLY Necessary to Ascertain Exposure Coverage in Safety Tests?-Reference-Cited by-同舟云学术

Meeting Report: Metabolites in Safety Testing (MIST) Symposium—Safety Assessment of Human Metabolites: What’s REALLY Necessary to Ascertain Exposure Coverage in Safety Tests?

Published:2013-07-03 Issue:4 Volume:15 Page:970-973
ISSN:1550-7416
Container-title:The AAPS Journal
language:en
Short-container-title:AAPS J

Author:

Gao Hongying,Jacobs Abigail,White Ronald E.,Booth Brian P.,Obach R. Scott

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Link

http://link.springer.com/content/pdf/10.1208/s12248-013-9502-6.pdf

Reference16 articles.

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2. Hastings KL, El-Hage J, Jacobs A, Leighton J, Morse D, Osterberg RE. Letter to editor. Toxicol Appl Pharmacol. 2003;190:91–2.

3. Smith DA, Obach RS. Metabolites and safety: what are the concerns, and how should we address them? Chem Res Toxicol. 2006;19:1570–9.

4. Timmerman P, Kall MA, Gordon B, Laakso S, Freisleben A, Hucker R. Best practices in a tiered approach to metabolite quantification: views and recommendations of the European Bioanalytical Forum. Bioanalysis. 2010;2:1185–94.

5. Yu CP et al. A rapid method for quantitatively estimating metabolites in human plasma in the absence of synthetic standards using a combination of LC/MS and radiometric detection. Rapid Commun Mass Spectrom. 2007;21:497–502.

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