Prediction of Drug Clearance in Children: an Evaluation of the Predictive Performance of Several Models

Author:

Mahmood Iftekhar,Staschen Carl-Michael,Goteti Kosalaram

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Reference55 articles.

1. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE. Developmental pharmacology—drug disposition, action, and therapy in infants and children. N Engl J Med. 2003;349:1157–67.

2. Gibaldi M. Gastrointestinal absorption: Physicochemical considerations. In: Biopharmaceutics and clinical pharmacokinetics. 3rd ed. Philadelphia: Lea and Febiger; 1984.

3. McNammara PJ, Alcorn J. Protein binding predictions in infants. AAPS PharmaSci. 2002;4:1–8.

4. Blanco JG, Harrison PL, Evans WE, et al. Human cytochrome P450 maximal activities in pediatric versus adult liver. Drug Metab Disp. 2000;28:379–82.

5. Cresteil T. Onset of xenobiotic metabolism in children: toxicological implications. Food Addit Contam. 1998;15:45–51.

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